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pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers boost charge of toremifene metabolism, lowering the steady-point out concentration in serum.pentobarbital will reduce the level or effect of quinine by impacting hepatic/intestinal enzyme CYP3A4 metabolis